Wednesday, February 4, 2026

The Startup Alternative with Gabriela de Queiroz – O’Reilly


Generative AI within the Actual World

Generative AI within the Actual World: The Startup Alternative with Gabriela de Queiroz



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Ben Lorica and Gabriela de Queiroz, director of AI at Microsoft, discuss startups: particularly, AI startups. How do you get seen? How do you generate actual traction? What are startups doing with brokers and with protocols like MCP and A2A? And which safety points ought to startups look ahead to, particularly in the event that they’re utilizing open weights fashions?

Try different episodes of this podcast on the O’Reilly studying platform.

In regards to the Generative AI within the Actual World podcast: In 2023, ChatGPT put AI on everybody’s agenda. In 2025, the problem will likely be turning these agendas into actuality. In Generative AI within the Actual World, Ben Lorica interviews leaders who’re constructing with AI. Be taught from their expertise to assist put AI to work in your enterprise.

Factors of Curiosity

  • 0:00: Introduction to Gabriela de Queiroz, director of AI at Microsoft.
  • 0:30: You’re employed with quite a lot of startups and founders. How have the alternatives for startups in generative AI modified? Are the alternatives increasing?
  • 0:56: Completely. The entry barrier for founders and builders is way decrease. Startups are exploding—not simply the quantity but in addition the fascinating issues they’re doing.
  • 1:19: You catch startups once they’re nonetheless exploring, making an attempt to construct their MVP. So startups must be extra persistent in looking for differentiation. If anybody can construct an MVP, how do you distinguish your self?
  • 1:46: At Microsoft, I drive a number of strategic initiatives to assist growth-stage startups. I additionally information them in fixing actual ache factors utilizing our stacks. I’ve designed applications to highlight founders. 
  • 3:08: I do quite a lot of engagement the place I assist startups go from the prototype or MVP to affect. An MVP will not be sufficient. I must see an actual use case and I must see some traction. Once they have actual clients, we see whether or not their MVP is working.
  • 3:49: Are you beginning to see patterns for gaining traction? Are they specializing in a particular area? Or have they got an excellent dataset?
  • 4:02: If they’re fixing an actual use case in a particular area or area of interest, that is the place we see them succeed. They’re fixing an actual ache, not constructing one thing generic. 
  • 4:27: We’re each in San Francisco, and fixing a particular ache or discovering a particular area means one thing completely different. Techie founders can construct one thing that’s utilized by their mates, however there’s no income.
  • 5:03: This occurs all over the place, however there’s a much bigger tradition round that right here. I inform founders, “You might want to present me traction.” We’ve got a number of firms that began as open supply, then they constructed a paid layer on prime of the open supply challenge.
  • 5:34: You’re employed with the parents at Azure, so presumably you understand what precise enterprises are doing with generative AI. Are you able to give us an concept of what enterprises are beginning to deploy? What’s the stage of consolation of enterprise with these applied sciences?
  • 6:06: Enterprises are a bit of bit behind startups. Startups are constructing brokers. Enterprises usually are not there but. There’s quite a lot of heavy lifting on the info infrastructure that they should have in place. And their use instances are complicated. It’s just like Large Knowledge, the place the enterprise took longer to optimize their stack.
  • 7:19: Are you able to describe why enterprises must modernize their knowledge stack? 
  • 7:42: Actuality isn’t magic. There’s quite a lot of complexity in knowledge and the way knowledge is dealt with. There’s quite a lot of knowledge safety and privateness that startups aren’t conscious of however are vital to enterprises. Even the sorts of knowledge—the info isn’t nicely organized, there are completely different groups utilizing completely different knowledge sources.
  • 8:28: Is RAG now a well-established sample within the enterprise?
  • 8:44: It’s. RAG is a part of all people’s workflow.
  • 8:51: The frequent use instances that appear to be additional alongside are buyer assist, coding—what different buckets are you able to add?
  • 9:07: Buyer assist and tickets are among the many fundamental pains and use instances. And they’re very costly. So it’s a simple win for enterprises once they transfer to GenAI or AI brokers. 
  • 9:48: Are you saying that the software builders are forward of the software patrons?
  • 10:05: You’re proper. I discuss quite a bit with startups constructing brokers. We focus on the place the business is heading and what the challenges are. For those who suppose we’re near AGI, attempt to construct an agent and also you’ll see how far we’re from AGI. Once you need to scale, there’s one other stage of issue. Once I ask for actual examples and clients, the bulk usually are not there but.
  • 11:01: A part of it’s the terminology. Folks use the time period “agent” even for a chatbot. There’s quite a lot of confusion. And startups are hyping the notion of multiagents. We are going to get there, however let’s begin with single brokers first. And you continue to want a human within the loop. 
  • 11:40: Sure, we discuss in regards to the human within the loop on a regular basis. Even people who find themselves bragging, while you ask them to indicate you, they’re not there but.
  • 12:00: On the agent entrance, if I requested you for a brief presentation with three slides of examples that caught your consideration, what would they be?
  • 12:30: There’s an organization doing an AI agent with emails and your calendar. Everybody makes use of electronic mail and calendars all day lengthy. If we need to schedule dinner with a gaggle of mates, however we’ve got individuals with dietary restrictions, it could take ceaselessly to discover a restaurant that checks all of the containers. There’s an organization making an attempt to make this computerized.
  • 14:22: In latest months, builders have rallied round MCP and now A2A. Somebody requested me for a listing of vetted MCP servers. If the server comes from the corporate that developed the appliance, high-quality. However there are millions of servers, and I’m cautious. We have already got software program provide chain points. Is MCP taking off, or is it a short lived repair?
  • 15:48: It’s too early to say that that is it. There’s additionally the Google protocol (A2A); IBM created a protocol; that is an ongoing dialogue, and since it’s evolving so quick, one thing will in all probability come within the subsequent few months.
  • 16:31: It’s very very like the web and the requirements that emerged from there. You can also make it formal, or you’ll be able to simply construct it, develop it, and one way or the other it turns into an empirical open commonplace.
  • 17:15: We’re implicitly speaking about textual content. Have you ever began to see near-production use instances involving multimodal fashions?
  • 17:37: We’ve seen some use instances with multimodality, which is extra complicated.
  • 17:48: Now you must develop your knowledge technique to all these completely different knowledge varieties.
  • 18:07: Going again to the slides: If I had three slides, I’d attempt to get everybody on the identical web page about what an AI agent is. All the massive firms have their very own definitions. I’d set the stage with my definition: a system that may take motion in your half. Then I’d say, in case you suppose we’re near AGI, attempt to construct an agent. And the third slide could be to construct one agent, moderately than a multiagent. Begin small, after which you’ll be able to scale, not the opposite manner round.
  • 19:44: Orchestration of 1 agent is one factor. Lots of people throw across the time period orchestration. For knowledge engineering, orchestration means one thing particular, and quite a bit goes into it, even for a single agent. For multiagents, it’s much more complicated. There’s orchestration and there’s communication too. An agent could withhold, ignore, or misunderstand data. So follow one agent. Get that accomplished and transfer ahead.
  • 20:33: The large factor within the foundational mannequin house is reasoning. What has reasoning opened up for a few of these startups? What functions depend on a reasoning-enhanced mannequin? What mannequin ought to I take advantage of, and may I get by with a mannequin that doesn’t cause?
  • 21:15: I haven’t seen any startup utilizing reasoning but. Most likely due to what you might be speaking about. It’s costly, it’s slower, and startups must see wins quick. 
  • 21:46: They only ask for extra free credit.
  • 21:51: Free credit usually are not ceaselessly. But it surely’s not even the associated fee—it’s additionally the method and the ready. What are the trade-offs? I haven’t seen startups speaking with me about utilizing reasoning.
  • 22:22: The sound recommendation for anybody constructing something is to be mannequin agnostic. Design what you’re doing so you need to use a number of fashions or change fashions. We now have open weights fashions which might be turning into extra aggressive. Final 12 months we had Llama; now we even have Qwen and DeepSeek, with an unimaginable launch cadence. Are you seeing extra startups choosing open weights?
  • 23:19: Positively. However they must be very cautious once they use open fashions due to safety. I see quite a lot of firms utilizing DeepSeek. I ask them about safety.
  • 23:43: Within the open weights world, you’ll be able to have spinoff fashions. Who vets the derivatives? Proprietary fashions have much more management. And there’s provide chain dangers, although they’re not distinctive to the open weights fashions. All of us rely on Python and Python libraries.
  • 25:17: And with individuals forking spinoff fashions. . . We’ve seen this with merchandise as nicely; individuals constructing merchandise and being worthwhile on prime of open supply initiatives. Folks constructed on a fork of a Python challenge or prime of Python libraries and [became] worthwhile. 
  • 25:55: With the Chinese language open weights fashions, I’ve talked to safety individuals, and there’s nothing inherently insecure about utilizing the weights. There is perhaps architectural variations. However in case you’re utilizing one of many Chinese language fashions of their open API, they may have to show over knowledge. Typically, entry to the weights isn’t a typical assault vector.
  • 27:03: Or you need to use firms like Microsoft. We’ve got DeepSeek R1 obtainable on Azure. But it surely’s gone by means of rigorous red-teaming and security analysis to mitigate dangers. 
  • 27:39: There are variations when it comes to alignment and red-teaming between Western and Chinese language firms.
  • 28:26: In closing, are there any parallels between what you’re seeing now and what we noticed in knowledge science?
  • 28:40: It’s comparable, however the scale and velocity are completely different. There are extra sources and accessibility. The barrier to entry is decrease. 
  • 29:06: The hype cycle is similar. You bear in mind all of the tales about “Knowledge science is the attractive new job.” However the know-how is now rather more accessible, and there are much more tales and extra pleasure.
  • 29:29: Again then, we solely had just a few choices: Hadoop, Spark. . . Not like 100 completely different fashions. They usually weren’t accessible to most of the people. 
  • 30:03: Again then individuals didn’t want Hadoop or MapReduce or Spark in the event that they didn’t have numerous knowledge. And now, you don’t have to make use of the brightest or best-benchmarked LLM; you need to use a small language mannequin.

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